Hong Wan Selected Research

EBI-1051

1/2018

Discovery of EBI-1051: A novel and orally efficacious MEK inhibitor with benzofuran scaffold.

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Hong Wan Research Topics

Disease

32	Neoplasms (Cancer) 05/2022 - 12/2002
11	Infections 09/2021 - 06/2006
6	Glioma (Gliomas) 11/2015 - 11/2011
4	Pemphigus (Pemphigus Vulgaris) 06/2021 - 05/2012
4	Facial Paralysis (Facial Palsy) 01/2020 - 09/2013
3	Meningioma (Meningiomas) 01/2022 - 06/2018
3	Squamous Cell Carcinoma of Head and Neck 01/2022 - 01/2009
3	Breast Neoplasms (Breast Cancer) 01/2021 - 10/2016
3	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 10/2019
3	Ovarian Neoplasms (Ovarian Cancer) 10/2020 - 11/2017
3	Hypercholesterolemia 05/2020 - 02/2018
3	Carcinogenesis 01/2018 - 11/2010
3	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 08/2003 - 02/2002
2	COVID-19 10/2022 - 01/2022
2	Cardiovascular Diseases (Cardiovascular Disease) 05/2022 - 01/2020
2	Inflammation (Inflammations) 01/2021 - 06/2003
2	Blister (Bulla) 01/2021 - 05/2012
2	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2021 - 05/2020
2	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2020 - 02/2018
2	Neoplasm Metastasis (Metastasis) 10/2019 - 12/2002
2	Pituitary Neoplasms (Pituitary Adenoma) 01/2018 - 09/2014
2	Carcinoma (Carcinomatosis) 01/2018 - 01/2011
2	Melanoma (Melanoma, Malignant) 01/2018 - 02/2016
2	Chordoma 09/2015 - 10/2013
2	Nausea 07/2013 - 11/2009
2	Headache (Headaches) 07/2013 - 11/2009
2	HIV Infections (HIV Infection) 01/2011 - 02/2010
2	Spinal Cord Injuries (Spinal Cord Injury) 09/2010 - 06/2007
2	Sepsis (Septicemia) 03/2007 - 06/2006
1	Ataxia Telangiectasia (Louis Bar Syndrome) 05/2022
1	Thoracic Aortic Aneurysm 05/2022
1	Hyperbilirubinemia 02/2022
1	Neonatal Hyperbilirubinemia 02/2022
1	Insulin Resistance 02/2022
1	Obesity 02/2022
1	Hepatitis C 01/2021

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 01/2022 - 05/2002
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2009
6	Pharmaceutical PreparationsIBA 12/2017 - 11/2009
5	letermovirIBA 09/2021 - 12/2017
5	Desmoglein 3IBA 06/2021 - 05/2012
5	Messenger RNA (mRNA)IBA 12/2019 - 09/2004
4	CytokinesIBA 05/2022 - 06/2006
4	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 03/2004
4	Cadherins (E-Cadherin)IBA 12/2019 - 05/2012
4	Biological ProductsIBA 06/2018 - 11/2011
4	Raltegravir Potassium FDA Link 01/2011 - 10/2007
3	InterleukinsIBA 05/2022 - 06/2003
3	EnzymesIBA 01/2022 - 10/2016
3	Transcription Factors (Transcription Factor)IBA 05/2020 - 11/2010
3	Proprotein Convertase 9IBA 01/2020 - 02/2018
3	efavirenz (Sustiva)FDA Link 01/2019 - 11/2009
3	CateninsIBA 07/2013 - 05/2013
3	Desmoplakins (Desmoplakin)IBA 08/2003 - 02/2002
2	molnupiravirIBA 10/2022 - 01/2022
2	Telomerase (Telomerase Reverse Transcriptase)IBA 05/2022 - 01/2011
2	Interleukin-6 (Interleukin 6)IBA 02/2022 - 01/2021
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022 - 01/2018
2	AutoantibodiesIBA 06/2021 - 01/2021
2	Peptides (Polypeptides)IBA 01/2021 - 01/2011
2	terminaseIBA 01/2020 - 01/2020
2	AntigensIBA 10/2019 - 08/2019
2	bococizumabIBA 02/2018 - 02/2018
2	Tyrosine Kinase InhibitorsIBA 12/2017 - 10/2016
2	pyrotinibIBA 12/2017 - 10/2016
2	EBI-907IBA 02/2016 - 01/2016
2	Brachyury protein (Brachyury)IBA 09/2015 - 10/2013
2	Protein Isoforms (Isoforms)IBA 05/2013 - 01/2011
2	Polyglactin 910IBA 09/2010 - 06/2007
2	Desmoglein 1IBA 08/2003 - 05/2002
1	Matrix Metalloproteinases (MMPs)IBA 05/2022
1	Metalloproteases (Metalloproteinases)IBA 05/2022
1	ProstaglandinsIBA 05/2022
1	1,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)IBA 05/2022
1	peptide-Gly-Leu-amideIBA 02/2022
1	LeptinIBA 02/2022
1	AdiponectinIBA 02/2022
1	Insulin (Novolin)FDA Link 02/2022
1	Therapeutic UsesIBA 02/2022
1	Glucose (Dextrose)FDA LinkGeneric 02/2022
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 02/2022
1	Blood Glucose (Blood Sugar)IBA 02/2022
1	salicylhydroxamic acid (SHAM)IBA 02/2022
1	AmidesIBA 01/2022
1	raf KinasesIBA 01/2022
1	Nicotinamide PhosphoribosyltransferaseIBA 01/2022
1	compound 18IBA 02/2021
1	shenqiIBA 01/2021
1	Interleukin-17 (Interleukin 17)IBA 01/2021
1	TabletsIBA 01/2021
1	Imiquimod (Aldara)FDA LinkGeneric 01/2021

Therapy/Procedure

9	Therapeutics 02/2022 - 10/2007
3	Immunotherapy 02/2021 - 01/2018
3	Cell Transplantation 10/2020 - 12/2017
3	Transplantation 12/2017 - 02/2007
2	Hematopoietic Stem Cell Transplantation 09/2021 - 01/2020
1	Phototherapy (Light Therapy) 02/2022
1	Aftercare (After-Treatment) 02/2022
1	Acupuncture Points (Acupuncture Point) 02/2022
1	Drug Therapy (Chemotherapy) 01/2021